张娟，女，副研究员，硕士研究生导师。皖南医科大学病理生理教研室专职教师。发表高影响力SCI论文40余篇，包括Neuron，Immunity，Cell Metabolism, Nature Structural & Molecular Biology, Protein & Cell, Science Bulletin等国际著名期刊，文章被引用合计4,000余次。获得国家自然科学基金委的多个项目支持，同时参与科技部以及中科院的多个科研项目。

主要研究方向：大脑衰老以及衰老相关的退行性疾病的机制研究。主要致力解析表观遗传机制在大脑衰老和神经退行性疾病中的调控功能。擅长从分子、细胞以及动物等多个层面对调控机制进行解析，同时探索疾病诊断的生物标志物以及寻找可能的药物干预靶标。

邮箱：zj2025@wnmc.edu.cn

学习教育经历：

2020/09-2023/12，安徽农业大学，生物学，博士。

2002/09-2005/06，中科院生物物理所，生物物理学，硕士。

近5年主持科研项目:

1. 国家自然基金委，面上项目，hnRNPK调控阿尔茨海默症病理进程的分子机制研究，2021/01-2024/12，55万元，结题，主持;

2. 安徽省教育厅科学研究项目，重大项目，YTHDF蛋白调控阿尔茨海默症的病理机制研究，，2026/01-2028/12，40万元，在研，主持；

近5年代表性文章:

1. Zhang J, Liu Q. Shedding light on interventions for brain aging. Immunity. 59(2):235-237, 2026. (IF:26.3)

2. Zhang J#, Li D#, He K, Liu Q*, Xie Z*. Aging-induced YTHDF aggregates impair mitochondrial function by trapping mitochondrial RNAs and suppressing their expression in the brain. Protein & Cell. 15(2):149-155, 2024. (# First author) (IF:21.1)

3. Zhang J, Liu Q. Age- and disease-related memory decline: epigenetic biomarker and treatment. Science Bulletin. 68(16):1719-1721, 2023. (IF:18.9)

4. Ding Z, Liu Q*, Zhang J*. SFRS8 regulates memory by modulating RNA splicing of synaptic genes. Molecular Neurobiology. 62(10):12523-12538, 2025 (* Corresponding author) (IF:5.6)

5. Li X#, Zhang J#*, Li D, He C, He K, Xue T, Wan L, Zhang C and Liu Q*. Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone acetylation-mediated memory. Neuron 109(6):957-970, 2021. (# First author) (IF:16.2)

6. Ma Y#, Zhang J#, Liu H#, Li D#, Guo S#, Wang L, Yu S, Su X, Gao Y, Lin X, Ciren Asan, Peng Y, Li G, Jiang H, Wang W, Yang H, Wang J, Zhu S, Zhao L*, Zhang J*, Liu Q*. Spatiotemporal characterization of disease-associated neurons in the entorhinal cortex-hippocampal circuit during AD progression. Protein & Cell. 16:799-814. 2025. (# First author) (IF:21.1)

7. Li D, Gao X, Ma X, Wang M, Cheng C, Xue T, Gao F, Shen Y, Zhang J *, Liu Q*. Aging-induced tRNA^Glu-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization. Cell Metabolism, 36(5): 1059-1075, 2024. (* Corresponding author) (IF:31.4)

8. Li D, Cao R, Li Q, Yang Y, Tang A, Zhang J*, Liu Q*. Nucleolus assembly impairment leads to two-cell transcriptional repression via NPM1-mediated PRC2 recruitment. Nature Structural & Molecular Biology. 30(7):914-925, 2023. (* Corresponding author) (IF:16.8)

9. Li W, Zhang J*, Liu Q*. Kin17 promotes rDNA transcription, ribosomal biogenesis, and cortical lamination. EMBO Reports. 26(17):4283-4311, 2025. (* Corresponding author) (IF:8.8)

10. Qiu Z, Liu Q*, Zhang J*. Loss of hepaCAM inhibits cholesterol biosynthesis and impairs learning and memory in mice. Brain Research. 1875:150183. 2026. (IF:3.2)

11. Li D, Zhang J*, Liu Q*. Mechanistic insights on non-coding RNAs in learning and memory. Science Bulletin. 68(15):1591-1594, 2023. (* Corresponding author) (IF:18.9)

12. Li D, Zhang J*, Liu Q*. Brain cell type-specific cholesterol metabolism and implications for learning and memory. Trends in Neurosciences. 45(5):401-414, 2022. (* Corresponding author) (IF:15.9)

13. Tang Y, Zhang J*, Liu Q*. tRNA-derived small noncoding RNAs: Roles in brain aging and neurodegenerative disorders. Zoology Research. 46(6):1575-1587. 2025. (* Corresponding author) (IF:4.0)

14. Ding M, Li D*，Zhang J*, Liu Q*. TAF15 overexpression impairs memory in mice by inhibiting the transcription of Npas4. Neuroscience Bulletin, 40:1937-1942, 2024. (IF:5.9)