博士、副教授，中共党员，硕士生导师。2020年6月毕业于中国科技大学，获细胞生物学博士学位；同年进入中国科学院合肥物质科学研究院博士后工作站；2022年7月出站并加入皖南医学院基础医学院，现为皖南医学院神经退行性疾病基础与转化医学团队（安徽省高校优秀科研创新团队）核心成员。团队经费充足，实验室条件优渥，仪器设备齐全完备。实验室（1号实验楼北6楼1620-1622）现配备有专业的分子实验室、细胞实验室、动物实验室和学生办公室兼会议室等功能区，能完成项目所需几乎所有实验。同时实验室配备有专职实验员3名，可协助指导实验。本人主要从事神经退行性疾病和肿瘤细胞死亡调控分子机制研究，以第一及通讯作者在Cell Death Disease、J Exp Clin Canc Res、Molecules、Scientific Reports等国际主流期刊发表SCI论文10篇，单篇最高被引220多次。主持有中国科学院合肥物质科学研究院青年“火花”基金、皖南医学院校级重点科研项目和安徽省教育厅重点科研项目等。担任Scientific Reports等期刊审稿人。

主要研究领域：细胞死亡调控分子机制与肿瘤化疗敏感性/神经退行性疾病基础与转化。

邮箱：huleiup@wnmc.edu.cn 。

代表性论文：

1. Qi Dong^#, Yanxia Ding^#, Yingxin Zhou^#, Xu Zhao, Lei Hu^*(共同通讯), Zhaohuan Zhang^*, Xiaohui Xu^*. Cmyc deletion in adult dopaminergic neurons leads to Klotho downregulation and Parkinson's disease-like pathology. Neural Regen Res. 2025.

2. Qianwen Yang, Changling Yue, Meng Chen, Yingying Ling, Qi Dong, Yingxin Zhou, Yin Cao, Yanxia Ding, Xu Zhao, Hai Huang, Zhaohuan Zhang ^*, Lei Hu ^*(共同通讯), Xiaohui Xu ^*. Daphnetin may protect from SARS-CoV-2 infection by reducing ACE2. Sci Rep. 2024, 28;14(1):30682.

3. Meng Chen^#, Shengli Ma^#, Wenbo Ji^#, Weihua Hu, Jiguang Gao, Jianke Yang, Yu Liu, Qianwen Cui, Shasha Yang, Xiaohui Xu^*, Haiming Dai^*, Lei Hu^*. Shenqi Sanjie Granules induce Hmox1-mediated ferroptosis to inhibit colorectal cancer. Heliyon, 2024, 10(18): e38021.

4. Lei Hu^#; Yu Liu^#; Changfang Fu; Jiarong Zhao; Qianwen Cui; Qiuyan Sun; Hongqiang Wang; Li Lu; Haiming Dai; Xiaohui Xu; Wulin Yang. The Tumorigenic Effect of the High Expression of Ladinin-1 in Lung Adenocarcinoma and Its Potential as a Therapeutic Target. Molecules, 2023, 28(3).

5. Meng Chen^#; Lei Hu^#（共同一作）; Xuyuan Bao; Kaiqin Ye; Yunjian Li; Zhiyong Zhang; Scott H. Kaufmann; Jun Xiao; Haiming Dai. Eltrombopag directly activates BAK and induces apoptosis. Cell Death & Disease, 2023, 14(7).

6. Lei Hu^#; Meng Chen^#; Haiming Dai; Hongzhi Wang; Wulin Yang. A Metabolism-Related Gene Signature Predicts the Prognosis of Breast Cancer Patients: Combined Analysis of High-Throughput Sequencing and Gene Chip Data Sets. Oncologie, 2022, 24(4): 803-822.

7. Lei Hu^#; Meng Chen^#; Xueran Chen; Chenggang Zhao; Zhiyou Fang; Hongzhi Wang; Haiming Dai. Chemotherapy-induced pyroptosis is mediated by BAK/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate. Cell Death & Disease, 2020, 11(4): 281.

8. Lei Hu^#; Xueran Chen^#; Meng Chen; Jinman Fang; Nie Jinfu; Haiming Dai. Enrichment and detection of circulating tumor cells by immunomagnetic beads and flow cytometry. Biotechnology Letters, 2020, 43(1): 25-34.

9. Xueran Chen^#; Lei Hu^#（共同一作）; Haoran Yang; Huihui Ma; Kaiqin Ye; Chenggang Zhao; Zhiyang Zhao; Haiming Dai; Hongzhi Wang; Zhiyou Fang. DHHC protein family targets different subsets of glioma stem cells in specific niches. Journal of Experimental & Clinical Cancer Research, 2019, 38(1): 25.

10. Lei Hu^#; Hao Li^#; Ruiying Qin; Rongfang Xu; Juan Li; Li Li; Pengcheng Wei,; Jianbo Yang. Plant phosphomannose isomerase as a selectable marker for rice transformation. Scientific Reports, 2016, 6(6): 25921.