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戚之琳

时间:2023-04-07 阅读次数:


女,教授,2014 年于南京师范大学获理学博士学位,2015年赴美国BloomfieldColleg访学,2019年获校学术和技术带头人称号。现任安徽省生物化学与分子生物学学会理事,主要从事疾病相关功能分子与细胞信号转导的相关研究,主持和参与国家自然科学基金及省级自然科学研究项目多项,主持和参与省级质量工程项目多项,发表学术论文20余篇。

邮箱:20010012@wnmc.edu.cn 

  

主持科研项目:

1. 国家自然科学基金青年基金,81601380,红景天苷抑制HMGB1核质转位及减弱HMGB1诱发“二次炎症”打击的分子机制2017/01-2019/12,17.5万元,结题,主持。

2.安徽高效自然科研研究项目重大项目,KJ2020ZD54,金盏花苷E经miRNA-200a-5p与MAPKs信号途径互作下调HMGB1抑制肝癌细胞增殖和迁移,2020-2023年,20万,在研,主持。

3. 2021年高校学科(专业)拔尖人才学术资助项目,gxbjZD2021060,2021-2023年,10万,在研,主持。

4. 2016安徽高校自然科学研究项目重大项目,KJ2016SD59,HSP70经β-attestin2介导通过激活Src-Akt/ERK信号途径抑制胃癌细胞凋亡,2016/01-2017/12,20万元,结题,主持。

5.安徽高校优秀青年人才支持计划重点项目,gxyqZD2016173,2016/01-2017/12,6万元,结题,主持。

部分代表性论文:

1.Tuo Tang, Shengnan Wang, Tianyu Cai, Zhenyu Cheng, Yu Meng, Shimei Qi, Yao Zhang, Zhilin Qi*, High mobility group box 1 regulates gastric cancer cell proliferation and migration via RAGE–mTOR/ERK feedback loop.Journal of Cancer,2021; 12(2): 518-529.

2.Shengnan Wang, Xuelei Chen, Jin Cheng, Tianyu Cai, Xiaoming Wu, Zhenyu Cheng, Shimei Qi, Zhilin Qi*. Calunduloside E inhibits HepG2 cell proliferation and migration via p38/JNK-HMGB1 signalling axis.Journal of Pharmacological Sciences.2021,147:18-26

3. Wang Ziqian, Tang Tuo, Wang Shennan, Cai Tianyu, Tao Hong, Zhang Qing, Qi Shimei, Qi Zhilin*. Aloin Inhibits the Proliferation and Migration of Gastric Cancer Cells by Regulating NOX2-ROS-Mediated Pro-Survival Signal Pathways. Drug Des Devel Ther. 2020,14:145-155.

4. Tao Hong, Tang Tuo, Wang Shengnan, Wang Ziqian, Ma Yunfei, Cai Tianyu, Cheng Xiuliang, Qi Shimei, Zhang Yao, Qi Zhilin*.The molecular mechanisms of Aloin induce gastric cancer cells apoptosis by targeting High Mobility Group Box 1. Drug Design, Development and Therapy 2019,13 1221–1231.

5. Lili Sheng, Tuo Tang, Yinhua Liu, Yunfei MA, Ziqian Wang, Hong Tao, Yao Zhang,Zhilin Qi*.Inducible HSP70 antagonizes cisplatin‑induced cell apoptosis through inhibition of the MAPK signaling pathway in HGC‑27 cells. International Journal of Molecular medicine, 2018,42: 2089-2097.

6. Yunfei MA, Tuo Tang, Lili Sheng, Ziqian Wang, Hong Tao, Qing Zhang, Yao Zhang and Zhilin Qi*.Aloin suppresses lipopolysaccharide‑induced inflammation by inhibiting JAK1‑STAT1/3 activation and ROS production in RAW264.7 cells. International Journal of Molecular medicine, 2018,42: 1925-1934.

7. Zhilin Qi*, Yao Zhang, Shimei Qi, Liefeng Ling, Lin Gui, Liang Yan, Jun Lv,and Qiang Li. Salidroside Inhibits HMGB1 Acetylation and Release throughUpregulation of SirT1 during Inflammation. Oxidative Medicine and Cellular Longevity, 2017, 2017:9821543.